MORE ABOUT TECHNOLOGY
Liposomal carriers of active substances must have specific features so they can be used rationally to supplement dietary deficiencies or treatment.
These are most important of them:
LIPOSHELL® liposomes, spherical carriers made of phospholipid molecules perfectly meet the above criteria.
Liposhell Technology see movie
Increased bioavailability has been confirmed by the clinical trial of the liposomal vitamin C ASCOLIP® produced on the basis of LIPOSHELL® technology.
The safety of using liposomes is ensured by their biocompatibility – the very structure of liposomal phospholipid bilayer resembles that of any organism’s cell membrane. Thanks to this biocompatibility, LIPOSHELL® liposomes are completely non-toxic and at the same time effectively release the active substance into the cells of human body.
Stability is ensured by a phospholipid bilayer, which protects the active substance against the action of e.g. digestive enzymes or bile salts. The phospholipid bilayer, which separates water enclosed within the sphere from the environment, is at the same time a robust barrier allowing controlled retention of the active substance.
Lipid bilayer has unique properties which can be used to efficiently close active substances. Thanks to this, they are protected against too rapid removal, and the body itself from undesired systemic side effects. Due to the coexistence of two permanently separated regions – the hydrophobic core of the bilayer and the water-filled liposome – it is possible to enclose many types of chemical compounds.
There are a number of well-defined methods of encapsulation of the active substances within liposomes.
There are passive and active methods. The passively loaded compounds become part of the carrier at the stage of the production. In contrast, active methods use proton gradient as the force that causes the molecules to move into the liposome.
Lipid Systems has a globally unique technology of efficient liposomal encapsulation of both hydrophilic (water soluble) and hydrophobic (fat soluble) substances.
The LIPOSHELL® technology allows to overcome the size barrier and to effectively encapsulate macromolecules such as proteins, polymers or bacteriophages in liposomes.
*PVP (Polyvinylpyrrolidone) is used as an ingredient for pharmaceuticals (mainly tablets), as a filler or binder (PVP as a polar substance binds well with other polar compounds) and in cosmetic and hygienic agents: it is added to shampoos, foams, hair conditioners, toothpastes and washing powders for coloured fabrics. It is marked as E1201.
