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Liposomes can be used as effective, advanced drug carriers, with properties specifically tailored to meet the intended purpose. The versatility of liposomal carriers results from the unique structural properties.
Molecules forming lipid bilayer determine its mechanical properties – rigidness, susceptibility to deformation, internal tensions. Changes of the bilayer composition directly affect these properties, which in turn affects both the behaviour of the carrier, and its interaction with the transported load, when injected into the body.
The properties of the drug protecting barrier may also vary depending on the environment , which allows selective release of the active substances in conditions of low pH in the cancerous tissues, or increased temperature of inflammatory tissues affected by disease.
The strategy of targeted drug carriers is based on the assumption that a biologically active substance can be effectively delivered to the selected place in the body without any need of exposing other areas.
In cells, the lipid bilayer is a barrier, the crossing of which is strictly controlled. This control is carried out through a number of mechanisms using the properties of the structure itself and the molecular machines connected to it. Liposomes are very similar to biological membranes. As a result, it is possible to modify the barrier protecting the enclosed active substance and release it under controlled conditions, e.g. in the vicinity of the disease affected tissues.
Knowledge of the physical and chemical properties of liposomal carriers allows designing structures, which environmental interactions allow strengthening the therapeutic effect, while limiting the side effects of the carried load.
The interactions between the carrier and the environment affect its distribution in tissues, excretion from the body and changing the effective local concentration of the drug, which increases effectiveness of the therapy. After fulfilling their task in the body, liposome carriers are degraded, and their components metabolised in the cells.
The creation of supramolecular tools allows solving a number of problems associated with the use of classic drug forms, including:
Results showing the effect of practical use of the LIPOSHELL® technology.
Chart shows data on liposomes size distribution measured by dynamic light scattering technique.
Chart shows the encapsulation efficiency of LIPOSHELL® technology for proteins and polymers.
